Pantothenic Acid (B5)
ECKLONIA CAVA Extract
B9 (folic acid)
Ashwagandha (Indian Ginseng)
7 Keto DHEA
7 Keto DHEA is a natural metabolite, or conversion product of DHEA. It’s a way to get the potential health benefits of DHEA without the associated risks, because 7 Keto DHEA, unlike DHEA proper, can’t be used by the body to make sex hormones, which have been shown to present a cancer risk. While our bodies produce DHEA naturally, from about age 20 production begins to decline, and this decline has been linked to diminished adrenal function and lack of energy, amongst other things. DHEA balances out excessive cortisol production, which is also known as the stress hormone. 7 Keto DHEA safely enhances immune function, memory, adrenal function and energy levels. It has also been shown to have thermogenic properties, increasing resting metabolism and helping with fat loss.
The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids, Volume 65, Issue 3, March 2000, Pages 124-129. Jennifer Shi, Stacy Schulze, Henry A. Lardy.
The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled trial. Current Therapeutic Research, Volume 63, Issue 4, April 2002, Pages 263-272. John L. Zenk, Tami R. Helmer, Laurie J. Kassen, Michael A. Kuskowski.
A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current Therapeutic Research, Volume 61, Issue 7, July 2000, Pages 435-442. Douglas S. Kaiman, Carlon M. Colker, Melissa A. Swain, Georgeann C. Torina, Qiuhu Shi.
Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clin Invest Med. 2000 Oct;23(5):300-10.Davidson M, Marwah A, Sawchuk RJ, Maki K, Marwah P, Weeks C, Lardy H.
Dehydroepiandrosterone and 7-keto DHEA augment interleukin 2 (IL2) production by human lymphocytes in vitro. Program Abstr 5th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 5th 1998 Chic Ill. 1998 Feb 1-5; 5th: 192 (abstract no. 596). Nelson R, Herron M, Weeks C, Lardy H; Conference on Retroviruses and Opportunistic Infections.
Pantothenic acid, or vitamin B5, is an essential nutrient required to sustain human life. It has been shown to increase cellular energy production and protect against oxidative cellular damage by increasing intracellular glutathione production. Pantothenic acid also improves wound healing and promotes a healthy inflammatory response. Adequate intake is necessary for the metabolism and synthesis of protein, carbohydrates and fats, for the functioning of the adrenal glands, and for proper immune function. Symptoms of pantothenic acid deficiency include depression, frequent infection, fatigue and sleep disturbances.
Comparative nutrition of pantothenic acid. The Journal of Nutritional Biochemistry, Volume 7, Issue 6, June 1996, Pages 312-321. Colleen M. Smith, Won O. Song.
Antagonism of L(-) pantothenic acid on lipid metabolism in animals. J Nutr Sci Vitaminol (Tokyo). 1980;26(2):113-7. Kimura S, Furukawa Y, Wakasugi J, Ishihara Y, Nakayama A.
Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Letters, Volume 569, Issues 1-3, 2 July 2004, Pages 169-172 Vyacheslav S. Slyshenkov, Dorota Dymkowska, Lech Wojtczak.
Pantothenic acid in health and disease. Vitam Horm. 1991;46:165-228. Tahiliani AG, Beinlich CJ.
Naturally derived from a species of brown algae found off the coast of Korea, ecklonia cava is a potent anti-oxidant and anti-inflammatory agent, serving to scavenge free radicals, chelate metals and donate electrons. It is a neuroprotective, potentially enhancing memory by increasing neurotransmitter levels. Ecklonia cava also has anti-bacterial properties, and is believed to function in wound healing processes, cell wall construction and vascular health.
Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food and Chemical Toxicology, Volume 44, Issue 7, July 2006, Pages 1065-1074. Yasantha Athukorala, Kil-Nam Kim, You-Jin Jeon
Antioxidant and antimicrobial activities of seaweed, Ecklonia cava. Journal of Biotechnology, Volume 136, Supplement 1, October 2008, Page S598. Yun Beom Kim, Young Gun Moon, Moon Soo Heo
Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-κB pathways. Food and Chemical Toxicology, Volume 47, Issue 2, February 2009, Pages 410-417. Won-Kyo Jung et al.
Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity Life Sciences, Volume 79, Issue 15, 5 September 2006, Pages 1436-1443. Moon-Moo Kim, Quang Van Ta, Eresha Mendis, Niranjan Rajapakse, Won-Kyo Jung, Hee-Guk Byun, You-Jin Jeon, Se-Kwon Kim
Antioxidant Potential of Ecklonia cava on Reactive Oxygen Species Scavenging, Metal Chelating, Reducing Power and Lipid Peroxidation Inhibition. Food Science and Technology International, Feb 2006; 12: 27 - 38.Mahinda Senevirathne, Soo-Hyun Kim, Nalin Siriwardhana, Jin-Hwan Ha, Ki-Wan Lee, and You-Jin Jeon
Antioxidative Properties of Brown Algae Polyphenolics and Their Perspectives as Chemopreventive Agents Against Vascular Risk Factors. Arch Pharm Res Vol 26, No 4, 286-293, 2003.Keejung Kang, Yongju Park, Hye Jeong Hwang, Seong Ho Kim, Jeong Gu Lee1, and Hyeon-Cheol Shin
Protective effect of Ecklonia cava enzymatic extracts on hydrogen peroxide-induced cell damage. Process Biochemistry, Volume 41, Issue 12, December 2006, Pages 2393-2401. Kil-Nam Kim, Soo-Jin Heo, Choon Bok Song, Jehee Lee, Moon-Soo Heo, In-Kyu Yeo, Kyoung Ah Kang, Jin Won Hyun, You-Jin Jeon
Improvement of Memory by Dieckol and Phlorofucofuroeckol in Ethanol-Treated Mice: Possible Involvement of the Inhibition of Acetylcholinesterase. Arch Pharm Res Vol 28, No 6, 691-698, 2005. Chang-Seon Myung, Hyeon-Cheol Shin1, Hai Ying Bao, Soo Jeong Yeo, Bong Ho Lee, and Jong Seong Kang.
Potassium is a naturally occurring element found in many fruits, vegetables and meats. It is necessary to maintain fluid and electrolyte balance in the body. It is also essential to cellular function, especially for brain and nerve cells, helping them communicate effectively. Potassium helps regulate osmotic pressure, keeping your cells ‘charged’ and the cell membrane strong. Potassium aspartate is a highly bioavailable and absorbable form of potassium.
Osmotic and ionic regulation in animals. Potts, W.T.W.; Parry, G. (1964). Pergamon Press: Oxford.
Effects of oral administration of aspartic acid salts on the endurance capacity of trained athletes. Res Q Exerc Sport 59 234-239 1988. Wesson, M. McNaughton L. Davies, P. Tristram, S.
Effects of potassium-magnesmium-aspartate on the capacity for prolonged exercise in man. Acta Physiol. Scand. 74:238-245; 1968. Ahlborg, B.; Ekelund, L. G.; Ndsson, C. G.
Antihypertensive effect of oral potassium aspartate supplementation in mild to moderate arterial hypertension. Biomedecine & Pharmacotherapy, Volume 59, Issues 1-2, January-February 2005, Pages 25-29. F. Franzoni, G. Santoro, A. Carpi, F. Da Prato, F. Bartolomucci, F.R. Femia, F. Prattichizzo, F. Galetta
Favourable effect of K, Mg aspartate on serum proteins in aging rats. Mechanisms of Ageing and Development, Volume 108, Issue 2, 3 May 1999, Pages 127-138. K. Chlebovská, O. Chlebovský
L'aspartate et son potentiel ergogène. Science & Sports, Volume 11, Issue 4, 1996, Pages 223-232. F Trudeau.
Treatment of fatigue in general practice: a double blind study. Clin Med. 1964 Jan; 71(1): 85-90. Hicks JT.
Management of fatigue: a physiologic approach. Am J Med Sci. 1962 Jun; 243: 758-69. Shaw DL, Chesney MA, Agersborg HP. ***
Magnesium is a naturally occurring nutrient essential to human life and cellular health. It maintains cellular membrane stability, and is required in order for your cells to be able to make and use energy. It also regulates neuromuscular, cardiovascular, immune and hormonal functions. The incidence of magnesium deficiency is disturbingly common, with up to 68% of the American population failing to meet the minimum recommended daily allowance. Magnesium deficiency is associated with a need for increased oxygen during exercise – athletes with low muscle magnesium levels are likely to use more energy and tire more quickly than those with adequate magnesium levels. Deficiency has also been associated with asthma, diabetes and osteoperosis.
Dietary Magnesium Depletion Affects Metabolic Responses during Submaximal Exercise in Postmenopausal Women. J. Nutr. 132:930-935, 2002. Henry C. Lukaski and Forrest H. Nielsen.
Magnesium metabolism and deficiency. Endocrinol. Metab. Clin. N. Am. 22:377-395. (1993) Rude, R. K.
Magnesium intakes, balances, and blood levels of adults consuming self-selected diets. Am. J. Clin. Nutr. 40:1380-1389. Lakshmanan, L. F., Rao, R. B., Kim, W. W. & Kelsay, J. L. (1984).
Low dietary magnesium increases supraventricular ectopy. Am. J. Clin. Nutr. 75:550-554. Klevay, L. M. & Milne, D. B. (2002).
Relationships between blood magnesium changes and physical performance. Golf, S. Dralle, D. Vecchiet, L. eds. Magnesium 1993 1994:247-251. John Libbey & Company London, UK. Gatteschi, L., Galvani, P., Orsi, F., Rubenni, M. G. & Resina, A. (1994).
Effects of magnesium supplementation on maximal and submaximal effort. Vecchiet, L. eds. Magnesium and Physical Activity. 1995:227-237 Parthenon Publishing Group London, UK. Vecchiet, L., Pieralisi, G., D’Ovidio, M, Dragani, L., Felzani, G., Mincarini, A., Giamberardino, M. A., Borella, P., Bargellini, A. & Piovanelli, P. (1995).
Les déficits en magnésium et le sport.Science & Sports, Volume 4, Issue 1, March 1989, Pages 41-52. D. Riche.
B vitamins are naturally occurring nutrients found in many foods and important for cellular energy and healthy metabolism. B vitamins also help maintain healthy muscle tone, support immune and nervous system function, and promote cell growth and division. They may also help alleviate stress, anxiety and depression. Our B complex contains all eight water-soluble B vitamins, including vitamin B1 (thiamine), B2 (riboflavin), B3 (niacin), B6 (pyridoxine), B7 (biotin), B9 (folic acid), B12 (cobalamin), and B5 (pantothenic acid).
Mitochondrial function and toxicity: Role of B vitamins on the one-carbon transfer pathways. Chemico-Biological Interactions, Volume 163, Issues 1-2, 27 October 2006, Pages 113-132. Flore Depeint, W. Robert Bruce, Nandita Shangari, Rhea Mehta, Peter J. O’Brien.
Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy of Sciences. Institute of Medicine. Food and Nutrition Board., ed (1998) Washington, D.C.: National Academy Press. ISBN 0-309-06411-2.
Vitamin B-12: Plant sources, requirements, and assay. Am. J. Clin. Nutr. 48 (3): 852–8. Herbert, Victor (1 September 1998).
Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. Am J Clin Nutr (June 2, 2010). Kimberly A Skarupski, Christine Tangney, Hong Li, Bichun Ouyang, Denis A Evans and Martha Clare Morris.
Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention. The Swiss Heart Study: A randomized controlled trial. JAMA., 2002, vol. 288, pp. 973—979. G. Schnyder, M. Roffi, Y. Flammer, et al. ***
Ashwagandha (Withania Somnifera), also known as Indian ginseng, is an herb used in Ayurvedic medicine to treat anxiety and stress, and enhance brain function and overall vitality. It has a neuroprotective effect and has been shown to be effective in increasing mental alertness and stamina. It has also been shown to be an antioxidant and possess anti-cancer, anti-inflammatory and immune enhancing properties.
Antistressor effect of Withania somnifera. Journal of Ethnopharmacology, Volume 64, Issue 1, 1 January 1998, Pages 91-93. R. Archana, A. Namasivayam.
Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats. Hum Exp Toxicol 2005;24: 137–47. Ahmad M, Saleem S, Ahmad AS, Ansari MA, Yousuf S, Hoda MN, et al.
Long term changes in neocortical activity after chemical kindling with systemic pentylenetetrazol: an in vitro study. J Neurophysiol 1994;72:72–83. Barkai E, Grossman Y, Gutnic MJ.
Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression. Molecular Cancer Therapeutics 5 (6): 1434–45. Ichikawa H, Takada Y, Shishodia S, Jayaprakasam B, Nair MG, Aggarwal BB (June 2006).
Withania somnifera: An Indian ginseng. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 32, Issue 5, 1 July 2008, Pages 1093-1105. S.K. Kulkarni, Ashish Dhir.
Germanium sesquioxide is a naturally occurring organic trace element found in virtually all foods in minute quantities. It has been shown to be an immune enhancer, antioxidant, and to aid in heavy metal detoxification. It is not to be confused with germanium dioxide, which can have toxic effects on the body. Ignite Naturals uses only the highest quality organic germanium sequioxide, manufactured in the USA.
Therapeutic effects of organic Germanium. Medical Hypotheses, Volume 26, Issue 3, July 1988, Pages 207-215.Sandra Goodman.
Biological activities and antitumor mechanism of an immunopotentiating organogermanium compound, Ge-132 (Review). In Vivo 1, 189 – 203. Brutkiewicz, R. R., and Suzuki, F. (1987).
Germane facts about germanium sesquioxide: I. Chemistry and anticancer properties. J Altern Complement Med. 2004 Apr;10(2):337-44. Kaplan BJ, Parish WW, Andrus GM, Simpson JS, Field CJ.
Germane facts about germanium sesquioxide: II. Scientific error and misrepresentation. J Altern Complement Med. 2004 Apr;10(2):345-8. Kaplan BJ, Andrus GM, Parish WW.